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Forum -> Fahrbares -> Bock, Auto, Fahrrad -> Nootropics Dihexa Powder CAS

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Beiträge 9
# Thema - 08.10.2019 um 15:41 Uhr
Nootropics Dihexa Powder CAS

Catalogue number: H293745
Chemical name: N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa)
Synonyms: N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-ox ohexyl)-L-isoleucinamide
CAS Number: 1401708-83-5
Structure: Nootropics Dihexa Withcas: 1401708-83-5
Molecular form.: CHNO
Appearance: White Solid
Melting Point: >209°C (dec.)
Mol. Weight: 504.66
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)

Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.
References: McCoy, A., et al.: J. Pharm. Exp. Ther., 344, 141 (2013)
Dihexa powder, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models ofAlzheimer's disease-like mental impairment. In an assay of neurotrophicactivity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.

According to a patent, "Short duration safety studies with Dihexa have uncovered no apparenttoxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as anoncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation.


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